The research activity aims to develop innovative methodologies for assessing the efficacy of topical and transdermal administration of drugs. At present, shared and recognized in vivo assessment methods are missing for topical and transdermal drugs. The impedance spectroscopy applied to biological tissue is proposed as quantitative method for assessing the dosage. The research will also aim at developing a method for assessing the rate of drug bioavailability to provide immediate evidence on the rapid systemic absorption of a drug (e.g., diabetic patient receiving ultra-fast insulin). In this research, biological tissue models will be realized (e.g. by finite element simulations) and validated through experimental campaign. Different kinds of drugs will be classified according their electrical behavior. Algorithms will be created for assessing concentration and localization of a drug by elaborating the variation of the impedance spectrum in a biological tissue before and after administration. Portable and wearable devices able to quantify and localize a drug administered topically or transdermally delivered will be prototyped.